• pkm2 In humans the two primary bile acids CA and

  2019-05-13

  

  In humans, the two primary bile acids CA and CDCA make up approximately 70%–80% of the total bile pkm2 pool. DCA is the major secondary bile acid, which may account for approximately 20% of the total bile acid pool. Among all bile acid species, the secondary bile acid LCA is highly toxic. LCA is eff

• br The translational pipeline in biomedicine from bench to

  2019-05-13

  

  The translational pipeline in biomedicine (from bench to bedside) focused the attention of the global research gamma secretase inhibitors on delivery of results to patients. The notion was rapidly accepted, as shown by the training of researchers in translational approaches, the establishment of

• br There is growing recognition that children bear a

  2019-05-13

  

  There is growing recognition that children bear a substantial burden of tuberculosis morbidity and mortality. However, in regions where the diagnosis is contingent on smear microscopy, the burden attributable to children, who usually have paucibacillary disease, is grossly underestimated. The down

• Desde mediados de la d cada

  2019-05-13

  

  Desde mediados de la década de los sesenta, la embajada argentina pedía informes sobre las actividades políticas en general y sobre las consideradas subversivas en Guatemala. A juicio de la embajada, en 1978 no se podía analizar la “ola de violencia” en Guatemala sin incluirla en el contexto de lo q

• Diversos trabajos coinciden en mencionar el impacto positivo

  2019-05-13

  

  Diversos trabajos coinciden en mencionar el impacto positivo que la auh ha tenido en términos de inclusión y justicia social frente receptor tyrosine kinase la situación donde sólo había asignación familiar contributiva, a partir de variables macroeconómicas como la modificación de tasas de pobreza

• histamine receptors Paisey et al recently proposed

  2019-05-13

  

  Paisey et al. recently proposed a simple technique for recognizing an MI block. In their study, an abrupt change of the CS activation pattern during RF application, under left atrial appendage pacing from a distal-to-proximal to proximal-to-distal direction provided a reliable assessment of MI condu

• On the basis of this mechanism the prolonged RR interval

  2019-05-13

  

  On the basis of this mechanism, the prolonged RR interval with the patient\'s symptoms was likely a reflection of the progression of the AV block with an underlying first-degree AV block. Despite a first-degree AV block (420ms) during the short RP rhythm, a short PR interval (160ms) was observed wit

• Hydrogen peroxide H O is shown to readily promote

  2019-05-10

  

  Hydrogen peroxide (H2O2) is shown to readily promote EADs and triggered activity in isolated rat and rabbit ventricular myocytes by increasing both the L-type Ca channel (ICa-L) and late sodium currents (INa-L) [31–35]. However, this same stress fails to cause EADs in normal non-fibrotic cardiac tis

• In an effort to determine whether the primary tumour

  2019-05-10

  

  In an effort to determine whether the primary tumour might be responsible for “fertilising” the bone “soil” ready for the cancer “seed”, we recently found that a hypoxic gene signature, and more specifically the secreted enzyme lysyl oxidase (LOX) was closely associated with bone metastasis, specifi

• Economic sanctions have exacerbated the brutality of this co

  2019-05-10

  

  Economic sanctions have exacerbated the brutality of this conflict many-fold, removing any prospects for peace and reconciliation. We need some reality to gauge their manifold effects before Syria descends into another Iraq, the devastating health consequences of which were well documented. Syria u

• br Sustained monomorphic ventricular tachycardia br Monomorp

  2019-05-09

  

  Sustained monomorphic ventricular tachycardia Monomorphic VT is defined as sustained when lasting longer than 30s or requires earlier intervention due to haemodynamic instability [89]. Most commonly, sustained MMVT occurs in the setting of diseased myocardium, but may also be idiopathic, occurr

• The tumor microenvironment is enriched with

  2019-05-09

  

  The tumor microenvironment is enriched with EMVs that are derived not only by proliferating tumor cells, but also from infiltrating macrophages and neutrophils, and support tumor cell survival, growth, invasion and metastasis. Tumor derived EMVs also have the potential to modulate surrounding stroma

• I am delighted to introduce the inaugural issue of

  2019-05-09

  

  I am delighted to introduce the inaugural issue of . It is very likely that you are reading this online, this being an online-only journal, although we have also printed this first issue in order to showcase the journal to readers of . What is certain is that, in accessing this article, and all the

• br With respect to the

  2019-05-09

  

  With respect to the welfare of children and mothers, the transition from the Millennium Development Goals (MDGs) to Sustainable Development Goals (SDGs) is sometimes perceived as risky. The relevant MDGs had a focus on interventions to address maternal and child health, while the focus of the SDGs

• Phosphorus is essential for organic activity such

  2019-05-09

  

  Phosphorus is essential for organic activity such as cellular signal transduction, membrane transport, mineral metabolism, and egfr inhibitor exchange [1]. Bone and teeth store 80% of the total body phosphorus. Intracellular phosphorus consists of the form of organic compounds such as adenosine tri

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