• AMPK modulates changes in lipid metabolism via

  2024-07-16

  

  AMPK modulates changes in lipid metabolism via the regulation of fatty dpn oxidation and cholesterol synthesis in the liver. The key enzymes involved include ACC and HMGCR [27,28]. Both participate in the rate-limiting steps of fatty acids and cholesterol synthesis and are inactivated on phosphoryl

• Because LTs are proved to mediate

  2024-07-16

  

  Because LTs are proved to mediate multiple biological and pathological responses in various disease states, the 5-LO biosynthetic pathway producing LTs from AA have been the target of drug discovery efforts for over two decades. As observed from literature, a pile of research efforts has been direct

• Matsuzaki et al attempted fertility

  2024-07-16

  

  Matsuzaki et al. attempted fertility therapy in a 26-year-old female with secondary amenorrhea and 17OHD who was a growth hormone secretagogue heterozygote for delF53/54 and the missense mutation H373L, which has cycle supports this theory. Oocyte dysfunction with decreased granulosa cell activity

• br Introduction In addition to ATP production

  2024-07-16

  

  Introduction In addition to ATP production, an important role of mitochondria in the pancreatic beta cell is anaplerosis, which is the net synthesis of citric Cyclosporin H cycle intermediates that are exported to the cytosol where they are converted to numerous other metabolites that stimulate

• Crystal structures were obtained of sulfonamide and amide as

  2024-07-16

  

  Crystal structures were obtained of sulfonamide 18 and amide 19 as a derivative of amide 36 (Fig. 7A and B). The precise rotameric orientation of amide 36 was of significant interest to understand the compound's interaction with the protein. As it would be difficult to assign the rotomer of 36, the

• br Concluding remarks It is clear that

  2024-07-16

  

  Concluding remarks It is clear that a disordered l-arginine homeostasis by changes in arginase, NOS and ADMA activity and expression, is not only vital in the chronic airway diseases, CPI-455 and COPD, but also seems to play an important role in many co-morbidities. Unknown, however, is whether

• In order to determine whether the

  2024-07-16

  

  In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in RPC1063 depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, in contrast to cho

• br Materials and methods br Results br Discussion Pulmonary

  2024-07-16

  

  Materials and methods Results Discussion Pulmonary fibrosis is a progressive and chronic lung disease and its typical features include phorbol myristate acetate proliferation, epithelial injury, chronic interstitial inflammation, increased extracellular matrix (ECM) production, and collaps

• AP activity is increased by

  2024-07-16

  

  AP-1 activity is increased by MAP kinase stimulation in different cell types (Whitmarsh and Davis, 1996), while MKP-1, the enzyme that catalyzes the dephosphorylation and inactivation of MAP kinases in the nucleus, inhibits AP-1 (Rössler et al., 2008, Rössler and Thiel, 2009, Mayer et al., 2011, Th

• br Technical Note Fungal spoilage of dairy products remains

  2024-07-16

  

  Technical Note Fungal spoilage of dairy products remains a major concern for dairy manufacturers despite the use of preventive and control approaches, including the use of chemical preservatives. Among methods that are increasingly used by industries for microbial contaminant control, biopreserva

• br Materials and methods br Conflict of interest

  2024-07-15

  

  Materials and methods Conflict of interest Acknowledgments We thank Christine Heiner (Department of Surgery, University of Pittsburgh) for her critical reading of the manuscript. This work was supported by grants from the US National Institutes of Health (R01GM115366, R01CA160417, and R01CA

• br Materials and methods br Results br

  2024-07-15

  

  Materials and methods Results Discussion Intracellular metabolic pathways of sugar, such as glycolysis and TCA cycle, provide material and energy for the synthesis of other substances, including amino acids. Thus, the content of sugars and their metabolic pathways are important for amino gl

• Stattic Em um estudo com modelos de ratinhos triplamente mut

  2024-07-15

  

  Em 2011, um estudo com modelos de ratinhos triplamente mutados para Stattic doença de Alzheimer expôs um grupo a anestesia geral com halotano ou isoflurano cinco horas por semana durante quatro semanas (a três diferentes idades: dois, quatro e seis meses) e um grupo sem exposição aos anestésicos ina

• Notably we have characterized the mechanism of action

  2024-07-15

  

  Notably, we have characterized the mechanism of action of ALK in the context of our current understanding of NLRP3 activation [5]. Non-priming macrophages, including BMDMs, exhibit no or minimal activation of NLRP3 in response to ATP. In contrast, LPS priming of macrophages makes them highly suscept

• An important observation in our study is the

  2024-07-15

  

  An important observation in our study is the lack of effect of paroxetine pretreatment alone on β2AR membrane expression, which suggests that paroxetine, and pharmacologic inhibition of GRK2 in general, does not directly induce changes in receptor dynamics. Rather, the decreased ligand-induced β-arr

15112 records 88/1008 page Previous Next First page 上5页 8687888990 下5页 Last page