• ionophore Hepatic inflammation and fibrosis are hallmarks of

  2024-07-17

  

  Hepatic ionophore and fibrosis are hallmarks of the NASH phenotype and are thought to occur in a subset of patients with NAFLD. While it is hypothesized that therapeutic lowering of hepatic lipids will be sufficient to improve hepatic fibrosis and inflammation secondarily, this remains controversia

• These findings suggest that eventually

  2024-07-17

  

  These findings suggest that eventually more than one 12/15-lipoxygenase isoform may play a role in human atherosclerosis. Humans have two 12-lipoxygenases and two 15-lipoxygenases which show different expression patterns, substrate specificities and stereo-selective metabolism [1]. However, in Adox

• br Material and methods br Results br Discussion Although

  2024-07-17

  

  Material and methods Results Discussion Although we were not able to detect 12/15-LOX mRNA in the lungs of 12/15-LOX knockout mice substantial amounts of 15-HETE could be detected in BALF. In fact, significant synthesis of 15-HETE in 12/15-LOX mice have been already reported [17]. The redun

• Due to metabolic variations it is important to consider argi

  2024-07-17

  

  Due to metabolic variations, it is important to consider arginine metabolism and dependency in specific contexts to identify precise patterns. This is best illustrated for ASS: while ASS deficiency correlates with worse prognosis in sarcomas, ASS levels positively correlate with a poor prognosis in

• Heart failure is a chronic

  2024-07-16

  

  Heart failure is a chronic syndrome in which the heart is unable of pumping an adequate supply of blood to meet the metabolic requirements of the body or generating the required elevated ventricular filling pressures to maintain output [34]. Despite considerable advances in the treatment of heart fa

• AMPK modulates changes in lipid metabolism via

  2024-07-16

  

  AMPK modulates changes in lipid metabolism via the regulation of fatty dpn oxidation and cholesterol synthesis in the liver. The key enzymes involved include ACC and HMGCR [27,28]. Both participate in the rate-limiting steps of fatty acids and cholesterol synthesis and are inactivated on phosphoryl

• Because LTs are proved to mediate

  2024-07-16

  

  Because LTs are proved to mediate multiple biological and pathological responses in various disease states, the 5-LO biosynthetic pathway producing LTs from AA have been the target of drug discovery efforts for over two decades. As observed from literature, a pile of research efforts has been direct

• Matsuzaki et al attempted fertility

  2024-07-16

  

  Matsuzaki et al. attempted fertility therapy in a 26-year-old female with secondary amenorrhea and 17OHD who was a growth hormone secretagogue heterozygote for delF53/54 and the missense mutation H373L, which has cycle supports this theory. Oocyte dysfunction with decreased granulosa cell activity

• br Introduction In addition to ATP production

  2024-07-16

  

  Introduction In addition to ATP production, an important role of mitochondria in the pancreatic beta cell is anaplerosis, which is the net synthesis of citric Cyclosporin H cycle intermediates that are exported to the cytosol where they are converted to numerous other metabolites that stimulate

• Crystal structures were obtained of sulfonamide and amide as

  2024-07-16

  

  Crystal structures were obtained of sulfonamide 18 and amide 19 as a derivative of amide 36 (Fig. 7A and B). The precise rotameric orientation of amide 36 was of significant interest to understand the compound's interaction with the protein. As it would be difficult to assign the rotomer of 36, the

• br Concluding remarks It is clear that

  2024-07-16

  

  Concluding remarks It is clear that a disordered l-arginine homeostasis by changes in arginase, NOS and ADMA activity and expression, is not only vital in the chronic airway diseases, CPI-455 and COPD, but also seems to play an important role in many co-morbidities. Unknown, however, is whether

• In order to determine whether the

  2024-07-16

  

  In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in RPC1063 depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, in contrast to cho

• br Materials and methods br Results br Discussion Pulmonary

  2024-07-16

  

  Materials and methods Results Discussion Pulmonary fibrosis is a progressive and chronic lung disease and its typical features include phorbol myristate acetate proliferation, epithelial injury, chronic interstitial inflammation, increased extracellular matrix (ECM) production, and collaps

• AP activity is increased by

  2024-07-16

  

  AP-1 activity is increased by MAP kinase stimulation in different cell types (Whitmarsh and Davis, 1996), while MKP-1, the enzyme that catalyzes the dephosphorylation and inactivation of MAP kinases in the nucleus, inhibits AP-1 (Rössler et al., 2008, Rössler and Thiel, 2009, Mayer et al., 2011, Th

• br Technical Note Fungal spoilage of dairy products remains

  2024-07-16

  

  Technical Note Fungal spoilage of dairy products remains a major concern for dairy manufacturers despite the use of preventive and control approaches, including the use of chemical preservatives. Among methods that are increasingly used by industries for microbial contaminant control, biopreserva

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