• The present work together with our

  2020-07-30

  

  The present work, together with our previous study, offers a means of conferring collagen-binding integrin-, VWF- and DDR-reactivity upon an inert substrate. GPRGQOGVNleGFO is known to bind not only VWF and DDR2, but also DDR1 and SPARC (Secreted Protein Acidic and Rich in Cysteine) [20,52]. We ther

• As temperatures increase rates of spontaneous deamination al

  2020-07-30

  

  As temperatures increase, rates of spontaneous deamination also increase such that hyperthermophilic organisms must have efficient mechanisms for dealing with this potential hazard.8., 9. The hyperthermophile Methanococcus jannaschii has both a dCTP deaminase (encoded by the gene at locus MJ0430) an

• The term myeloproliferative disorders was first proposed by

  2020-07-30

  

  The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myeloproliferative dis

• br CDKs as Direct Coactivators of Proinflammatory Transcript

  2020-07-30

  

  CDKs as Direct Coactivators of Proinflammatory Transcription Factors CDKs fuel inflammation by triggering the function of proinflammatory transcription factors such as NF-κB, STAT3, and AP-1. This is achieved at two levels because CDKs can affect gene expression by targeting global transcription

• n-acetyl-l-cysteine In this study we discovered that CRM

  2020-07-30

  

  In this study, we discovered that CRM1 was increased in the intestinal tissues of patients with active CD in whom ser10-phosphorylated p27 was also elevated, whereas the expression of p27kip1 was decreased. In vitro experiments revealed that increased expression of CRM1 was consistent with elevated

• BI 6015 synthesis Conventional configurations for alkanolami

  2020-07-30

  

  Conventional configurations for alkanolamine and BI 6015 synthesis gas are not suitable to represent the chemical reaction between acid gas and alkanolamines. Nevertheless, Dowell et al. [17] have successfully represented the phase behaviour of CO2-water-MEA systems by using SAFT-VR [18] without an

• br Materials and methods br Results br Discussion

  2020-07-30

  

  Materials and methods Results Discussion In the present study, alprostadil, iloprost and L902688 (selective EP4 agonist) caused concentration-dependent relaxation of rat corpus cavernosum. The most effective as relaxant was the EP4 agonist followed by iloprost then alprostadil, suggesting t

• br Method of developing cox

  2020-07-30

  

  Method of developing cox regression models The measured variables influenced simultaneously the period from one operating status to another because the number of system components operating was controlled in response to the set point of and the calculated from the measured and . The period in

• The remainder of this paper is

  2020-07-30

  

  The remainder of this paper is organized as follows: Section 2 provides background on previous research about SE for scientific software. Section 3 describes the research methodology used in this systematic literature review. Section 4 reports the scientists’ and software engineers’ claims about SE

• Alternation of joints by mechanical stress

  2020-07-29

  

  Alternation of joints by mechanical stress produces microcracks and deterioration of natural pores in subchondral bone provides Okadaic acid for cross talk through diffusion of small molecules [26,27]. At early stage of OA, chondrocytes in the injured cartilage releases transforming growth factor b

• Together the results of the alkaline

  2020-07-29

  

  Together, the results of the alkaline elution and cell growth/cytotoxicity data strongly suggest that both the activity and DNA interstrand cross-linking produced by ZD2767P + CPG2 is due to bifunctionality of the active ZD2767D drug that is generated from ZD2767P. The monofunctional ZD2767D analogu

• br Experimental section br Results br

  2020-07-29

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised AZD0156 did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient by al

• Various domains of DDR have been

  2020-07-29

  

  Various domains of DDR1 have been shown to be important for receptor clustering and its oligomeric status. It is now understood that (i) dimerization [7] and higher-order oligomerization [12], [18] of the DDR1 extracellular domain (ECD) enhance its binding to collagen; (ii) DDR1 exists as non-covale

• Although human DHFR and TS reactions are

  2020-07-28

  

  Although human DHFR and TS reactions are catalyzed by separate, monomeric enzymes, in some plants and protozoa, these two Pancuronium dibromide exist in a dimer structure with four active sites, including two TS active sites and two DHFR active sites (8, 9), as in L. major and Plasmodium falciparum

• The DDRs can interact with multiple proteins and also modula

  2020-07-28

  

  The DDRs can interact with multiple proteins and also modulate signaling pathways initiated by other matrix receptors, cytokines,growth factors, and transmembrane receptors in a context- and cell-type-dependent manner.3, 4 We therefore evaluated the consequences of DDR2 activation on potential downs

15154 records 772/1011 page Previous Next First page 上5页 771772773774775 下5页 Last page