• The annotation is arguably the most important part of

  2020-11-05

  

  The annotation is arguably the most important part of analysis, as it enables one to evaluate and interpret the content of the transcriptome assembly. In this context, the non-redundant contigs were initially run in BLAST against the Nr database showing that 55% of them displayed high similarity to

• In recent years the use

  2020-11-05

  

  In recent years, the use of liquid chromatography/tandem mass spectrometry (LC–MS/MS) has become a preferred approach to measure drugs and metabolites in biological fluids due to its very high selectivity and sensitivity [17], [18], [19], [20], [21], [22], [23], [25], [30]. The great sensitivity of

• Previous research has suggested that the acetylcholine gated

  2020-11-05

  

  Previous research has suggested that the acetylcholine-gated chloride channels (ACCs) in Caenorhabditis elegans (Putrenko et al., 2005) exhibit the characteristics of promising drug targets. The genes that encode the various subunits of this family are present across the nematode phylum and appear t

• br Materials and methods br Results br Discussion Cells

  2020-11-05

  

  Materials and methods Results Discussion Cells in the human body, especially in the cardiovascular and musculoskeletal systems, undergo a variety of mechanical stimuli. In order to ensure human movement, the strength of stretching muscles acts on cartilage and bone, moving joints through te

• Our observation that nuclear but not cytoplasmic

  2020-11-04

  

  Our observation that nuclear, but not cytoplasmic EP4 expression is associated with different outcomes is interesting. In breast cancer, using the same methods, we did not detect EP4 in the nucleus of malignant hedgehog inhibitor whereas cytoplasmic EP4 was commonly observed [13]. While G protein-c

• Several studies have demonstrated that Syn specifically asso

  2020-11-04

  

  Several studies have demonstrated that αSyn specifically associates with lipid rafts (Cole et al., 2002), raising the possibility that the perturbation of rafts can affect the aggregation and phosphorylation of αSyn (Fortin et al., 2004). Schneider et al. (2010) described the potential involvement o

• PTEN is an evolutionarily conserved protein and

  2020-11-04

  

  PTEN is an evolutionarily conserved protein and has been considered to be genetically unique without other isoforms. In this study, we identified an alternate translation initiation at a CUG site in the 5′ untranslated region (5′ UTR) of PTEN mRNA. This CUG start wee1 generates a larger form of PTEN

• Despite the important agronomic traits regulated by SUMO mos

  2020-11-04

  

  Despite the important agronomic traits regulated by SUMO, most research studies on SUMOylation have been mainly limited to model plants, such as Arabidopsis and rice (Wang et al., 2011), due to the lack of molecular tools specific to other economically relevant plants. On the other hand, plants harb

• br Experimental Procedures br Author Contributions M

  2020-11-04

  

  Experimental Procedures Author Contributions M.B., with input and help from T.T.H., conceived the project, designed and performed the experiments, analyzed the data, and wrote the manuscript. B.B.B. and F.D.M. synthesized the wild-type and (nonhydrolyzable, NH) Ub tetramers and contributed Fig

• The other scenario pertaining to

  2020-11-04

  

  The other scenario pertaining to the significance of H2AX phosphorylation is based on the fact that the initiation of DNA fragmentation by CAD facilitates the chromatin condensation that occurs concurrently [15]. Apoptotic DNA fragmentation and chromatin condensation are important for the efficient

• br Conflict of Interest br

  2020-11-04

  

  Conflict of Interest Acknowledgements Marques F. was supported by the Foundation for Science and Technology (FCT), Portugal, Grant UMINHO/BI/35/2012. This work was supported by FCT by the Project PTDC/AGR-AAM/70418/2006. Introduction β-methylamino-l-alanine (BMAA) exposure has long been as

• 1 25-dihydroxyvitamin d3 receptor An increasing body of evid

  2020-11-04

  

  An increasing body of evidence demonstrates that MXC can cause neurobehavioral and neuropathological alterations [7]. In the brain, there are several steroidogenic enzymes, which are responsible for neurosteroid production. Neurosteroids are subsets of steroids that rapidly change neuronal excitabil

• The absorption rate of polyphenols into

  2020-11-04

  

  The Guvacoline hydrobromide rate of polyphenols into the body is usually low. For example, the absorption rate of epigallocatechin gallate (EGCG), an active component in GP, is approximately 1% (Chen et al., 1997). To increase absorption of GP in the body, people have been increasing their intake of

• This review focuses on the atomic basis of CRM

  2020-11-04

  

  This review focuses on the atomic basis of CRM1-mediated nuclear export. There are now 27 crystal structures of CRM1 in the Protein Data Bank (PDB) (www.rcsb.org) [64]. Collectively, this large body of work explains various aspects of CRM1 function. Here we summarize the structure–function studies t

• br Advantages of modified proteins over

  2020-11-04

  

  Advantages of modified proteins over unmodified ones In contrast to small-molecule drugs, proteins are readily amenable to site-specific alterations through genetic engineering. In principle, therefore, it is possible to build in features that allow them to remain active for longer in the body an

15466 records 749/1032 page Previous Next First page 上5页 746747748749750 下5页 Last page