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Introduction Breast cancer is a highly prevalent malignancy
2020-11-30
Introduction Breast cancer is a highly prevalent malignancy. There are some recognized risk factors for breast cancer, like early menarche or late menopause, which increase the length of the exposure to hormones, as a result of a higher number of ovarian cycles [1]. Moreover, there is evidence supp
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ARQ 621 br Discussion EFTs are sarcomas with almost undiffer
2020-11-30
Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular ARQ 621 on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI1 immunohistoche
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(R,S)-Anatabine synthesis br Methods br Discussion and
2020-11-30
Methods Discussion and conclusions There were no statistically significant differences in pulmonary function outcomes (FEV1 and FVC) between the placebo and BAY 85-8501 treatment groups. The decline in mean FEV1 from baseline to EOT in the placebo group was attributed statistically to a few pa
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A decrease in heme levels enables the phosphorylation of
2020-11-30
A decrease in heme levels enables the phosphorylation of eIF2α by HRI and thereby inhibition of eIF2α activity. Indeed, the relatively small change in cytosolic heme levels in SZ 2×Taq PCR Master Mix(with dye) showed downstream functional consequences manifested by almost 50% elevation in the phosph
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MicroRNA miRNA is a class of highly conserved
2020-11-28
MicroRNA (miRNA) is a class of highly conserved, non-coding small molecules containing 19–25 nucleotides. miRNAs are involved in the regulation of genes associated with cancer development and progression and therefore can act as oncogenes, by contributing to tumor formation,17, 18 or as tumor suppre
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Based on the SUMO SIM interaction involved
2020-11-28
Based on the SUMO–SIM interaction involved in SUMOD positioning, a SUMO2ΔSBD (SIM-binding domain; Q30A, F31A, I33A) mutant can be investigated that disrupts this important binding interface (Eisenhardt et al., 2015; Meulmeester, Kunze, Hsiao, Urlaub, & Melchior, 2008). In Fig. 4A, multiturnover assa
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br Conclusions br Acknowledgements br Introduction Liver
2020-11-28
Conclusions Acknowledgements Introduction Liver cancer was the fifth most common cancer and the second leading cause of cancer-related death worldwide [1]. Most of primary liver cancers (70–90%) occurring worldwide are hepatocellular carcinoma (HCC) [2]. Persistent hepatitis B virus (HBV) i
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This hydrophobic biphenyl tail gave good binding
2020-11-28
This hydrophobic biphenyl tail gave good binding affinity for human DHODH enzyme (IC Clofazimine was found to be the main metabolite in human microsomes and it was 100-fold less active against hDHODH than the ester. In an attempt to identify the specific non-covalent binding interactions which wer
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The first purpose of the current study was
2020-11-28
The first purpose of the current study was to characterize a standardized experimental model of postprandial hyperlipidemia in various rodent species. To our knowledge this study provides the most comprehensive and systematic evaluation of rodent models of postprandial hyperlipidemia to date. We ada
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While these previous correlative studies have measured tDDR
2020-11-28
While these previous correlative studies have measured tDDR1 protein by IHC, these studies have not considered that pDDR1 could also be an important marker of cancer prognosis. A phosphoproteomic survey of lung cancer tissues did identify pDDR1 as one of the most commonly phosphorylated receptor kin
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We hypothesized that the atopic phenotype may be partially i
2020-11-28
We hypothesized that the atopic phenotype may be partially influenced by an altered binding and/or signalling due to the amino-acid substitution in the receptor protein. The principal aim of this study was to investigate the signalling mechanisms of the variants CysLT1-G300S and CysLT1-I206S induced
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The present results are potentially
2020-11-28
The present results are potentially relevant for understanding anxiety disorders and their treatment. Both COMT Val158Met (Lonsdorf and Kalisch, 2011, Montag et al., 2012) and neuroticism/anxiety (Clark et al., 1994, Mineka et al., 1998, Weinstock and Whisman, 2006) have been linked to the prevalenc
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br Acknowledgements These studies were
2020-11-28
Acknowledgements These studies were supported by a research grant from the NIH (R01 AR065594) to C. Putterman. Introduction Macrophages integrate and adapt to their locally encountered cytokine and chemokine milieu. In tumors characterized by an unresolving inflammation, the tumor cell-killin
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Although the findings detailed above provide ample evidence
2020-11-28
Although the findings detailed above provide ample evidence that the activity of the CRF1 receptor in the amygdala plays a role in the acute and chronic effects of alcohol exposure, several important areas of investigation remain understudied. The majority of the work on CRF1-alcohol interactions ha
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To determine the time course of
2020-11-28
To determine the time course of ZD2767P+CPG2 DNA–DNA interstrand cross-link formation, HT29 and LS174T colorectal tumour 6-Bnz-cAMP sodium salt were exposed to the drug for 10, 30 or 60 min. The levels of DNA interstrand cross-links in HT29 or LS174T cells did not increase with exposure time, sugges
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