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Distribution of DGTS in basidiomycete fungi has been
2021-08-25

Distribution of DGTS in basidiomycete fungi has been demonstrated to be heterogeneous. In certain fungal taxons, such as Agaricales, Polyporales and Russulales, there are species that synthesize and species that do not synthesize DGTS that belong to the same order or even family (Dembitsky, 1996, Va
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The COMT gene is involved in numerous psychological and phys
2021-08-24

The COMT gene is involved in numerous psychological and physiologic processes, including modulation of pain. Polymorphisms in this gene have also been associated with many painful conditions, including pain sensitivity in children. Bivariate analysis demonstrated that individuals with heterozygous C
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Recently we have created CRISPR Cas mediated col
2021-08-24

Recently, we have created CRISPR/Cas9-mediated col14a1a knockout fish to interrogate the function of col14a1a during regeneration using the caudal fin model. Using AFM, we showed that collagen XIV-A transiently acts as a molecular spacer responsible for BM biomechanics possibly by helping laminins i
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Several cholinesterase inhibitors have also been radiolabell
2021-08-24

Several cholinesterase inhibitors have also been radiolabelled with 11C as potential cholinesterase imaging agents. These include 11C-donepezil, 11C-methyltacrine, and 11C-physostigmine, which also have had limited success in demonstrating the known histochemically defined cholinesterase distributio
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A neurotoxic syndrome called Intermediate syndrome has been
2021-08-24

A neurotoxic syndrome called “Intermediate syndrome” has been described after acute cholinergic crisis, which has been interpreted as the result of pre- and postsynaptic disruptions of neuromuscular transmission (Senanayake and Karalliedde, 1987). Other toxic effects with unknown molecular targets h
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The N B method has the overall advantage that
2021-08-24

The N&B method has the overall advantage that it is not restricted to certain dyes specific for energy transfer [55], and is also able to detect higher order receptor carnosic acid on the focal point in living cells. Conclusion The N&B method has shown to be a powerful tool to locate and quanti
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Materials and Methods br Results
2021-08-24

Materials and Methods Results Discussion For several decades, the diagnosis of translocation-associated childhood sarcomas with overlapping morphological characteristics has been facilitated by pathognomonic gene fusion detection through RT-PCR or FISH. However, these assays have several shor
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Two primary members of the TRIM family
2021-08-24

Two primary members of the TRIM family – TRIM5α and TRIM25 – function as antiviral effector and immune regulator, respectively. TRIM5α is one of the best characterized members of the TRIM family (both structurally and functionally) and reported to be an important ubiquitin-mediated regulator of a ma
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The present study is a genetic association study using
2021-08-24

The present study is a genetic association study using the classic candidate gene approach. This method has been repeatedly criticized in the past to produce highly unreliably findings (e.g. Flint & Munafò, 2013). The alternative would be the conduction of a T-5224 mg wide association study (GWAS).
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br Acknowledgements Thanks are due to Science and Technology
2021-08-23

Acknowledgements Thanks are due to Science and Technology Development Fund – Egypt for the Research Support Technology Development Grant (RSTDG) no. 12626. Our deep thanks and gratitude is also extended to National Cancer Institute (NCI), Bethesda, Maryland, USA for performing the anticancer eval
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So far few studies have been
2021-08-23

So far few studies have been conducted on the role of chemokines in patients with PTSD and avoidant personality disorders. Ogłodek et al. [10] in her studies found an increase in the level of the chemokine CCL-5 in patients with avoidant personality disorder and general anxiety disorder (GAD) as com
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br Introduction Proteins therapeutic can be defined as
2021-08-23

Introduction Proteins therapeutic can be defined as proteins that are either naturally produced in the body or created in the laboratory and introduced into the patient with the aim of improving or curing a pathological condition. They are usually acquired from either microbial stavudine receptor
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The present results are potentially relevant for understandi
2021-08-23

The present results are potentially relevant for understanding anxiety disorders and their treatment. Both COMT Val158Met (Lonsdorf and Kalisch, 2011, Montag et al., 2012) and neuroticism/anxiety (Clark et al., 1994, Mineka et al., 1998, Weinstock and Whisman, 2006) have been linked to the prevalenc
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It has previously been shown that human melanocytes
2021-08-23

It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of thymidylate synthase inhibitor on human melanocytes led to inconsistent data [12], [13]. Im et al. [1
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br Management of Hypertension The
2021-08-23

Management of Hypertension The aim of treating HT is to reduce the risk of adverse cardiovascular outcomes: mainly coronary artery disease, stroke, and death. For this reason, the decision whether to initiate pharmacological treatment or not will depend not only on BP values, but also on the over
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