• DNA repair is essential for cell survival and

  2021-11-24

  

  DNA repair is essential for cell survival and for tissue homeostasis given that cellular DNA is constantly challenged by various endogenous and exogenous genotoxic factors that generate DNA damage: structural and chemical modifications of a primary DNA sequence. Various organisms have evolved multip

• FFAR is highly expressed not only in cells but also

  2021-11-24

  

  FFAR1 is highly expressed not only in β cells but also in α CGS 35066 (Segerstolpe et al., 2016), which gives the interesting perspective that 20-HETE may function both as an autocrine and as a paracrine regulator of islet cell function (Figure 1A), i.e., acting in symphony with the many other intr

• (Z)-4-Hydroxytamoxifen To confirm that these were bona fide

  2021-11-24

  

  To confirm that these were bona fide interactions, we investigated whether the potassium channel subunits or Tmem263 formed complexes with GLT-1 or DAT after immunoprecipitation. Lysates of HEK-293 cells previously cotransfected with HA-GLT-1 or HA-DAT, and either YFP-Kv7.3, YFP-Kv7.2 or YFP-Kv7.5 w

• The HH Gli pathway has been demonstrated

  2021-11-24

  

  The HH-Gli pathway has been demonstrated to play an extensive role in skeletal development. India Hedgehog, derived from hypertrophic chondrocytes, and Parathyroid Hormone-like related Protein (PTHrP), derived from peri-articular chondrocytes, form a negative feedback loop to inhibit chondrocyte hyp

• Although GLP has greater insulin releasing effects at

  2021-11-24

  

  Although GLP-1 has greater insulin-releasing effects at pharmacological concentrations [10], it is apparent that the higher circulating concentrations of GIP combined with more pronounced increase in secretion following feeding make GIP the major physiological incretin [7], [11]. The peptide exerts

• To date three GAL subtype receptors have

  2021-11-24

  

  To date, three GAL subtype receptors have been cloned and characterized, GALR1, GALR2 and GALR3. However, it is unknown which one(s) of the three subtype receptors in toll like receptor is most effective to regulate insulin resistance in diabetic rats as yet. Recent studies fromanimalmodels of diabe

• Recently we indicated that cell motility was regulated

  2021-11-24

  

  Recently, we indicated that cell motility was regulated by the different induction of GPR120 and GPR40 in liver epithelial WB-F344 cannabinoid receptors treated with chemical agents. The cell motility of WB-F344 cells was stimulated by phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) which i

• A new series of pyrimidones with

  2021-11-24

  

  A new series of pyrimidones (14) with C-7 and C-9 modifications were furnished consisting of a hydroxypyridinone and a thiazole ring and checked against raltegravir resistant HIV mutant strains to determine their in vitro anti-HIV IN potency. Compounds 14a–14a, 14b–14b and 14c–14c appeared with 6.4 

• Parkinson s disease is another neurodegenerative disorder af

  2021-11-24

  

  Parkinson's disease is another neurodegenerative disorder affecting H3Rs. The most common clinical symptoms of this disease are rigidity, bradykinesia, rest tremor, loss of postural reflexes, and gain impairment owing to progressive degeneration of the dopaminergic neurons in the nigro-striatal neur

• The molecular mechanism of gliotransmitter release

  2021-11-24

  

  The molecular mechanism of gliotransmitter release is not fully understood until now, and previous studies have emphasized that the elevation of [Ca2+]i triggers vesicular CID 2745687 of glutamate. Parpura et al. reported that the essential role of Ca2+ release from internal stores in glutamate rele

• In the present study fasting blood

  2021-11-24

  

  In the present study, fasting blood glucose and insulin levels were not significantly different between GA patients and control cases. Normal mammalian cells typically acquire fatty acids from the circulation owing to insulin, which is the most lipogenic hormone in the subset of adult tissues, inclu

• Recently IL was also identified as an

  2021-11-24

  

  Recently, IL-10 was also identified as an important mediator of collagen deposition in the development of HF [64,65]. It was shown, that this cytokine activates macrophages found in the hearts of mice suffering from diastolic dysfunction in the autocrine manner [64]. In response, specific subset of

• As GSH cellular redox status is

  2021-11-23

  

  As GSH cellular redox status is critical for various biological phenomena including apoptosis and inflammation [34], [35] we hypothesized that inflammation could modulate GSTP1-1 gene expression. Indeed, reactive oxygen species (ROS) are released at inflammation sites and can be eliminated from surv

• That means br TGR Agonists br FXR

  2021-11-23

  

  TGR5 Agonists FXR/TGR5 Dual Agonists In 2010, a FXR/TGR5 dual agonist, 51 (INT-767), was reported [57]. Using an AlphaScreen coactivator recruitment assay, the potency of 51 at FXR was 30nM. In NCI-H716 cells, 51 stimulated intracellular cAMP secretion with an EC50 of 0.63μM. Its TGR5 potency

• elastase br Glucose metabolism and diet Glucokinase is

  2021-11-23

  

  Glucose metabolism and diet Glucokinase is essential for sensing blood glucose levels, thus controls metabolism (Iynedjian, 1993, Iynedjian, 2009, Postic et al., 2001, Agius, 2008). Loss of glucokinase activity in humans and mice leads to diabetes (Printz et al., 1993b, Postic et al., 2001, Agius

15517 records 528/1035 page Previous Next First page 上5页 526527528529530 下5页 Last page