• Apoptosis a form of programmed cell death

  2021-11-19

  

  Apoptosis, a form of programmed cell death, is a critical component in maintaining homeostasis and growth in all tissues and plays a significant role in immunity and cytotoxicity [54,55]. Although GR are expressed in all immune cells, the physiological outcomes of GR activation are highly cell type-

• Ghrelin readily crosses the blood brain barrier Banks et al

  2021-11-19

  

  Ghrelin readily crosses the blood Metronidazole barrier (Banks et al., 2002, Banks et al., 2008), and recent studies have identified central nervous system sites of action for ghrelin-mediated appetite and hyperphagia (Alvarez-Crespo et al., 2012, King et al., 2011, Schele et al., 2016, Skibicka et

• tolbutamide br Novel mechanisms of fipronil

  2021-11-19

  

  Novel mechanisms of fipronil resistance in planthoppers Conclusion Conflict of interest Introduction Methamphetamine, a widely abused drug, is mainly used as a psychostimulant although it is occasionally used at low doses for medical purposes, such as in attention deficit or hyperactivit

• Knock out mice of FXR

  2021-11-19

  

  Knock-out mice of FXR showed enhancing cholesterol metabolism in vivo and reducing serum levels of total cholesterol. Additionally, the results of FXR-deficiency mice revealed potential effects on the improvement of obesity and diabetes.19, 20 As a natural FXR ligand, guggulsterone possesses antagon

• br Experimental section br Acknowledgements This study was

  2021-11-19

  

  Experimental section Acknowledgements This study was supported by grants from the National Natural Science Foundation of China (Grants 81673299 and 81273376). Introduction Free fatty acids (FFAs) are important metabolic fuels and those that are polyunsaturated are essential components of t

• br STAR Methods br Acknowledgments We thank P Adler V

  2021-11-19

  

  STAR★Methods Acknowledgments We thank P. Adler, V. Riechmann, N. Tapon, E. Knust, the Vienna Drosophila RNAi Center, the Australian Drosophila Research Support Facility (www.ozdros.com), the Bloomington Drosophila Stock Center, and the Developmental Studies Hybridoma Bank for D. melanogaster s

• The Fe deficiency treatment significantly increased the

  2021-11-19

  

  The Fe-deficiency treatment significantly increased the shoot/root Fe ratios in both WT and transgenic lines (Fig. 5C), which implied that the Fe distribution from root to shoot may be an adaptive mechanism or stress response in tomato plants. Thus, the overexpression of GSNOR had a positive effect

• Recent work by Que et al with mouse models implicates

  2021-11-19

  

  Recent work by Que et al with mouse models implicates GSNOR in the cause of asthma. GSNOR is expressed in multiple cell types in the lung, including airway epithelial cells and infiltrating leukocytes. After exposure to ovalbumin, GSNOR activity increased in airway lining fluid, perhaps reflecting i

• br Materials and methods br Results br

  2021-11-19

  

  Materials and methods Results Discussion Although there is general agreement that GPR109A has anti-lipolytic activity and that the NEFA reduction in response to nicotinic 8-CPT-Cyclic AMP sodium salt is mediated by GPR109A, whether GPR109A activation has any impact on plasma TG levels is u

• To apply the recently developed GPR ligands to CNS disorders

  2021-11-19

  

  To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the Phos-tag Acrylamide and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. To this

• GLP is an intestinal peptide hormone that

  2021-11-19

  

  GLP-1 is an intestinal peptide hormone that is released by the gut following ingestion of food, particularly Alogliptin australia and fats. Following its release, GLP-1 stimulates pancreatic β-cells to secrete insulin (Hirasawa et al., 2005, Covington et al., 2006). Originally, GLP-1 acted in a sim

• The top concern for the clinical

  2021-11-19

  

  The top concern for the clinical use of CRISPR-Cas9 technology is safety. Off-target alterations must be avoided to ensure genome integrity and proper cellular function. WGS found no off-target effects among the top 49 predicted off-target sites. WGS did find 4,658 indels and 1,891 SNVs in sgRNA1/2-

• Compared to methadone or morphine buprenorphine is

  2021-11-19

  

  Compared to methadone or morphine, buprenorphine is a partial mu-opioid agonist, which shows high affinity for, and slow dissociation from, mu-opioid receptors. This maintenance of homeostasis may help to counter the development of an overt withdrawal syndrome, and may explain the lower risk of deve

• We first investigated the influence of

  2021-11-19

  

  We first investigated the influence of the -acyl group of the glycine amide side chain and found that shorter linkers lead to better activities (–); simple -benzoyl substituents were always superior to the 3-arylpropanoyl group present in the high-throughput hit (). Electron withdrawing substituents

• In addition to the increase of

  2021-11-18

  

  In addition to the increase of extracellular glutamate, ICH can also increase the levels of reactive oxygen species (ROS) and oxidative stress. Although the products of red blood cell lysis and plasma components, as well as the excitotoxic effect of glutamate have been to increase oxidative damage (

15466 records 527/1032 page Previous Next First page 上5页 526527528529530 下5页 Last page