• As the communications interface was developed by two separat

  2021-04-15

  

  As the communications interface was developed by two separate organisations with differing software processes and tools, a modular approach to the safety case was deemed appropriate. The modular approach related the communications interface safety argument to the safety arguments for both the ACS an

• br Discussion The present study found cholinesterase activit

  2021-04-15

  

  Discussion The present study found cholinesterase activity in Saccostrea sp. to vary significantly among three tissue types (digestive gland, gills, adductor muscle) and to respond differentially to four toxicants, three of which were non-organophosphates. Furthermore, a comparison of enzyme acti

• Additionally both in vitro and in

  2021-04-15

  

  Additionally, both in vitro and in vivo studies showed that a Ca2+ influx is closely related to apoptosis (Rizzuto et al., 2003). Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells, which senses intracellular calcium levels by bindi

• br Introduction As a serine

  2021-04-15

  

  Introduction As a serine proteinase and a sub-family of the chymotrypsin-like proteinase, Glutamyl endopeptidase (GE), which is mainly found in Bacillus species, specifically cleaves negatively charged amino Fmoc-Ala-OMe residues (Glu/Asp) (Yokoi et al., 2001). Madsen et al. (Madsen & Qvist, 199

• In some cases more than one CYP enzyme may

  2021-04-15

  

  In some cases, more than one CYP450 enzyme may be involved in the metabolism of a drug, and an Eadie–Hofstee plot is usually more reliable for assessing the involvement of multiple LY294002 (Bu, 2006). Therefore, we first plotted the Eadie–Hofstee curves and observed their shape to determine the ki

• Neuronal cells have highly developed ER which makes

  2021-04-15

  

  Neuronal TAE684 have highly developed ER, which makes them susceptible to loss of ER function following exposure to various agents, which leads to apoptosis (Lindholm et al., 2006, Katayama et al., 2004). Multiple pathways may be involved in ER stress-initiated apoptosis. Among them, the PKR-like en

• br Significance Dysregulation of dopamine homeostasis contri

  2021-04-14

  

  Significance Dysregulation of dopamine homeostasis contributes to Parkinson's disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of NS-398 synthesis governing the synthesis, packaging, and reuptake of dopamine. Efforts to capitalize

• br Introduction In most of the

  2021-04-14

  

  Introduction In most of the angiosperms, sexual reproduction requires a process called double fertilization where the specialized cell division called meiosis produces haploid gametes combine to form diploid (2n) embryo. In DIG-11-dUTP mg to this, apomixis, naturally occurs in at least 400 plant

• Sotalol Diacylglycerol kinases DGK and are lipid

  2021-04-14

  

  Diacylglycerol kinases (DGK) α and ζ are lipid kinases that limit diacylglycerol (DAG)-dependent activation pathways downstream of the TCR (Merida et al., 2015). Their upregulation in tumor infiltrating lymphocytes (TIL) has been linked to generation of hyporesponsive states that contribute to immun

• br Discussion Electroporation is a convenient and

  2021-04-14

  

  Discussion Electroporation is a convenient and efficient way to introduce foreign material into ARCA [10], [16], [17], [18]. There are a lot of different protocols for transfection with electroporation. It was reported that there are several parameters that are relevant to successful electroporat

• br General Characteristics of the Type II Dehydrogenases

  2021-04-14

  

  General Characteristics of the Type II Dehydrogenases Alternative NAD(P)H dehydrogenases conduct the reaction of the rotenone-insensitive oxidation of cytosolic and mitochondrial matrix NADH and/or NADPH (Fig. 1) (Melo et al., 2004, Rasmusson et al., 2004, Rasmusson et al., 2008). They catalyze t

• br Contributors br Acknowledgements br Introduction

  2021-04-14

  

  Contributors Acknowledgements Introduction Pemphigus disorders are characterized by autoantibodies binding to desmosomes between epidermal cells, resulting in the loss of cell to cell adhesion and blister formation. In pemphigus foliaceus, autoantibodies predominantly bind to desmoglein 1,

• During the course of our research

  2021-04-14

  

  During the course of our research on mGlu PAMs,, the hydroxyacetophenone scaffold was found to possess dual mGlu PAM and CysLT1 antagonism activity, presumably as orthosteric antagonist (). There is currently an increasing interest in drug discovery to explore multitarget drugs or polypharmacology

• br Conflicts of interest br Acknowledgments

  2021-04-14

  

  Conflicts of interest Acknowledgments Work in the laboratory of SPS is funded by Council of Scientific and Industrial Research (CSIR) Network Project BSC-0111 (INDEPTH) and BSC-0112 (NanoSHE). We are thankful to Director, CSIR-IITR for his constant encouragement and support. We also acknowledg

• br Conclusion br Conflict of interest br Acknowledgments

  2021-04-14

  

  Conclusion Conflict of interest Acknowledgments The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding the work through the research group project No. RGP-120. Introduction Methods Results Conclusions Introduction Pat

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